Search results for "polycaprolactone and polylactic acid film"

Improvement of actinorhodin production yield in Streptomyces coelicolor by immobilized-cell cultivations by using PCL- and PLA-based films

2016

Actinomycetes are Gram-positive bacteria producing most of naturally occurring antibiotics (Donadio et al., 2010). At industrial level, antibiotics are produced by submerged fermentations where the actinomycete filamentous morphology negatively affects bioproductivity (van Dissel et al., 2014). Microporous membranes for bacterial cell-immobilization were already proven increasing bioproductivity in Streptomyces coelicolor, that is a model actinomycete producing the blue pigmented actinorhodin (ACT) antibiotic (Scaffaro et al., 2016). To develop an immobilized-cell bioreactor system, different kinds of polycaprolactone (PCL) and polylactic acid (PLA) films were produced by an electrospinning…